参考文献

[1] AGGELI A，BELL M，BODEN N，et al.Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheettapes[J].Nature， 1997， 386（6622）：259-262.

[2] AGGELI A，BELL M，CARRICK L M，et al.pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases[J].J Am Chem Soc，2003，125（32）：9619-9628.

[3] BAB I，GAZIT D，CHOREV M，et al.Histone H4-related osteogenic growth peptide （OGP）：a novel circulating stimulator of osteoblastic activity[J].EMBO J，1992，11（5）：1867-1873.

[4] BIAN L，GUVENDIREN M，MAUCH R L，et al.Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis[J].Proc Natl Acad Sci，2013，110（25）：10117-10122.

[5] BOOPATHY A V，MARTINEZ M D，SMITH A W，et al.Intramyocardial delivery of notch ligand-containing hydrogels improves cardiac function and angiogenesis following infarction[J].Tissue Eng，Part A，2015，21（17-18）：2315-2322.

[6] BRAY S J.Notch signalling：a simple pathway becomes complex[J].Nat Rev Mol Cell Biol，2006，7（9）：678.

[7] BRUNTON P A，DAVIES R P，BURKE J L，et al.Treatment of early caries lesions using biomimetic self-assembling peptides--a clinical safety trial[J].Br Dent J，2013，215（4）：E6.

[8] CAPRINI A，SILVA D，ZANONI I，et al.A novel bioactive peptide：assessing its activity over murine neural stem cells and its potential for neural tissue engineering[J].New Biotechnol，2013，30（5）：552-562.

[9] CHAMBERLAIN L J，YANNAS I V，ARRIZABALAGA A，et al.Early peripheral nerve healing in collagen and silicone tube implants：myofibroblasts and the cellular response[J].Biomaterials，1998，19（15）：1393-1403.

[10] CHAU Y，LUO Y，CHENG A C，et al.Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides—a model for biofunctional scaffolds[J].Biomaterials，2008，29（11）：1713-1719.

[11] ELLIS-BEHNKE R G，LIANG Y X，YOU S W，et al.Nano neuro knitting：peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision[J].Proc Natl Acad Sci USA，2006， 103（13）：5054-5059.

[12] FALANGA V，ISAACS C，PAQUETTE D，et al.Wounding of bioengineered skin：cellular and molecular aspects after injury[J].J Inv Dermatol，2002， 119（3）：653-660.

[13] GELAIN F，BOTTAI D，VESCOVI A，et al.Designer selfassembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures[J].PloS One，2006，1（1）：e119.

[14] GELAIN F，SILVA D，CAPRINI A，et al.BMHP1-derived self-assembling peptides：hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications[J].ACS Nano，2011， 5（3）：1845-1859.

[15] Genove E，Shen C，Zhang S，et al.The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function[J].Biomaterials， 2005， 26（16）：3341-3351.

[16] GIANO M C，POCHAN D J，SCHNEIDER J P.Controlled biodegradation of self-assembling beta-hairpin peptide hydrogels by proteolysis with matrix metalloproteinase-13[J].Biomaterials，2011， 32（27）：6471-6477.

[17] HAINES-BUTTERICK L，RAJAGOPAL K，BRANCO M，et al.Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells[J].Proc Natl Acad Sci USA，2007，104（19）：7791-7796.

[18] HARTGERINK J D，BENIASH E，STUPP S I.Self-assembly and mineralization of peptide-amphiphile nanofibers[J].Science （New York，NY），2001，294（5547）：1684-1688.

[19] HORII A，WANG X，GELAIN F，et al.Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation，differentiation and 3-D migration[J].PloS One ，2007，2（2）：e190.

[20] HSIEH P C H，DAVIS M E，GANNON J，et al.Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers[J].J Clinical Invest，2006，116（1）：237-248.

[21] HSU W C，SPILKER M H，YANNAS I V，et al.Inhibition of conjunctival scarring and contraction by a porous collagen-glycosaminoglycan implant[J].Invest Ophthalmol Visual Sci，2000，41（9）：2404-2411.

[22] ICHIHARA Y，KANEKO M，YAMAHARA K，et al.Selfassembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure[J].Biomaterials，2018，154：12-23.

[23] LI A，HOKUGO A，YALOM A，et al.A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers[J].Biomaterials，2014， 35（31）：8780-8790.

[24] LI R，XU J，WONG D S H，et al.Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonicalWnt/β-catenin signaling[J].Biomaterials，2017，145：33.

[25] LI X，CHEN Y Y，WANG X M，et al.Image-guided stem cells with functionalized self-assembling peptide nanofibers for treatment of acute myocardial infarction in a mouse model[J].Am J Transl Res，2017，9（8）：3723-3731.

[26] LIU X，WANG X，HORII A，et al.In vivo studies on angiogenic activity of two designer self-assembling peptide scaffold hydrogels in the chicken embryo chorioallantoic membrane[J].Nanoscale，2012，4（8）：2720-2727.

[27] LOO Y，WONG Y C，CAI E Z，et al. Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds[J].Biomaterials，2014，35（17）：4805-4814.

[28] LUNDBORG G，GELBERMAN R H，LONGO F M，et al. In vivo regeneration of cut nerves encased in silicone tubes：growth across a six-millimeter gap[J].J Neuropathol Exp Neurol，1982，41（4）：412-422.

[29] MATSON J B，AND STUPP S I.Self-assembling peptide scaffolds for regenerative medicine[J].Chem Commun（Cambridge，UK），2012， 48（1）：26-33.

[30] MENG H，CHEN L，YE Z，et al. The effect of a self-assembling peptide nanofiber scaffold （peptide）when used as a wound dressing for the treatment of deep second degree burns in rats[J].J Biomed Mater Res， Part B，2009，89（2）：379-391.

[31] PAN H，HAO S，ZHENG Q，et al. Bone induction by biomimetic PLGA copolymer loaded with a novel synthetic RADA16-P24 peptide in vivo[J].Mater Sci Eng C Mater Biol Appl，2013， 33（6）：3336-3345.

[32] PASHUCK E T，CUI H，STUPP S I.Tuning supramolecular rigidity of peptide fibers through molecular structure[J].J Am Chem Soc，2010，132（17）：6041-6046.

[33] PUGLIESE R，GELAIN F.Peptidic biomaterials：from selfassembling to regenerative medicine[J].Trends Biotechnol，2017，35（2）：145-158.

[34] SAINI A，SERRANO K，KOSS K，et al.Evaluation of the hemocompatibility and rapid hemostasis of（RADA）4 peptide-based hydrogels[J].Acta Biomater，2016，31：71-79.

[35] SCHNEIDER A，GARLICK J A，EGLES C.Self-assembling peptide nanofiber scaffolds accelerate wound healing[J].PloS One，2008， 3（1）：e1410.

[36] SHAH R N，SHAH N A，DEL ROSARIO LIM M M，et al. Supramolecular design of self-assembling nanofibers for cartilage regeneration[J].Proc Natl Acad Sci USA，2010， 107（8）：3293-3298.

[37] SUN L，ZHENG C，WEBSTER T J.Self-assembled peptide nanomaterials for biomedical applications：promises and pitfalls[J].Int J Nanomed，2017，12：73-86.

[38] TAO H，WU Y，LI H，et al. BMP7-based functionalized self-assembling peptides for nucleus pulposus tissue engineering[J].ACS Appl Mater Interfaces，2015，7（31）：17076-17087.

[39] TYSSELING-MATTIACE V M，SAHNI V，NIECE K L，et al. Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury[J].J Neurosci，2008，28（14）：3814-3823.

[40] WANG X，WANG J，GUO L，et al. Self-assembling peptide hydrogel scaffolds support stem cell-based hair follicle regeneration[J].Nanomedicine，2016，12（7）：2115-2125.

[41] WANG X，WANG X，LIU J，et al. Hair follicle and sebaceous gland de novo regeneration with cultured epidermal stem cells and skin-derived precursors[J].Stem Cells Transl Med，2016，5（12）：1695-1706.

[42] WU X，HE L，LI W，et al. Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration[J].Regener Biomater，2007，4（1）：21-30.

[43] XIONG N，DONG X Y，ZHENG J，et al. Design of LVFFARK and LVFFARK-functionalized nanoparticles for inhibiting amyloid β-Protein fibrillation and cytotoxicity[J].ACS Appl Mater Interfaces，2015，7（10）：5650-5662.

[44] YANG H，YANG H，XIE Z，et al.Self-assembling nanofibers alter the processing of amyloid precursor protein in a transgenic mouse model of Alzheimer’s disease[J].Neurol Res，2015，37（1）：84-91.

[45] YANNAS I V，BURKE J F.Design of an artificial skin.I.Basic design principles[J].J Biomed Mater Res，1980，14（1）：65-81.

[46] YERGOZ F，HASTAR N，CIMENCI C E，et al.Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury[J].Biomaterials，2017，134：117-127.

[47] YOSHIDA M，GOTO N，KAWAGUCHI M，et al.Initial clinical trial of a novel hemostat，TDM-621，in the endoscopic treatments of the gastric tumors[J].J Gastroenterol Hepatol，2014，29（4 suppl）：77-79.

[48] ZAULYANOV L，KIRSNER R S.A review of a bi-layered living cell treatment（Apligraf）in the treatment of venous leg ulcers and diabetic foot ulcers[J].Clin Interventions Aging，2007，2（1）：93-98.

[49] ZHANG M，AI W W，MEI Z L，et al.Delivery of biotinylated IGF-1 with biotinylated self-assembling peptides combined with bone marrow stem cell transplantation promotes cell therapy for myocardial infarction[J].Exp Ther Med，2017，14（4）：3441-3446.